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For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses

Approved injection sites: Abdomen (except 2 inches around navel), thigh (front and outer), back of upper arm

Convergent evidence has demonstrated favorable effects of C

These intermediate steps can help if you experienced significant side effects at a previous dose increase

In moderate to severe UC, the first-line therapy for induction is a glucocorticoid or biological agent