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The LEADER trial enrolled patients with T2DM and high cardiovascular risk, defined as established CVD (81%) or age 60 years with at least one risk factor, and showed that liraglutide significantly reduced the incidence of 3-point major adverse cardiovascular events (MACE) (i.e., CV death, non-fatal myocardial infarction, non-fatal stroke) by 13% compared to placebo (HR 0.87

J Chem Inf Model 61:38913898 Gu X, Mu C, Zheng R, Zhang Z, Zhang Q, Liang T (2024) The cancer antioxidant regulation system in therapeutic resistance

By applying firm, gentle pressure to the skin just before and during an injection, it helps distract the nerves so the brain focuses more on touch and pressure rather than pain

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Rather than broadly disrupting the mucosal barrier, they actively shuttle the therapeutic peptide across the epithelium through targeted mechanisms