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It can promote the differentiation and maturation of immune cells, modulate cytokine production, and contribute to wound healing and tissue repair (van Harten et al., 2018)

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OPs in T cells, microglia/macrophages, astrocytes, oligodendrocytes, and neuron in the CNS of MS patients reduces Nrf2 and increases NF-kB, and may promote the release of inflammatory cytokines

Estrogen dissociates Tau and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit in postischemic hippocampus

Efficacy and safety of upadacitinib in patients with giant cell arteritis (SELECT-GCA): a double-blind, randomized controlled phase 3 trial [abstract]