Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
Human trials remain limited, so much of the discussion comes from preclinical research, clinician experience, and user reports
It may take a bit of leg work, but be your own best advocate
The combination of reduced caloric intake (from tirzepatide appetite suppression) and enhanced fat breakdown (from AOD 9604 lipolysis) creates a steeper downward trajectory
Signs and Symptoms of Deficiency rapid breathing or shortness of breath headaches indigestion loss of appetite palpitations problems with your vision feeling weak or tired diarrhoea a sore or red tongue, sometimes with mouth ulcers problems with memory, understanding and judgment (cognitive changes) Numbness Muscle Weakness Where do I get Vitamin B12 From
