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local anesthetic applied Injection Points: Typically include the AC joint capsule and coracoclavicular ligament attachments Solution Used: 15-25% dextrose + 1% lidocaine or procaine Guidance: Can be done freehand or under ultrasound guidance for precision Post-Injection Care Mild soreness or swelling is expected for 13 days Avoid anti-inflammatory medications (they may blunt the desired response) Gentle range of motion exercises encouraged Physical therapy may be added at any time Treatment Frequency Prolotherapy is typically performed every 34 weeks 36 sessions are usually recommended depending on severity and how you are progressing Clinical Evidence Supporting Prolotherapy for AC Joint Injury While large randomized controlled trials are limited for AC separation specifically, prolotherapy has demonstrated efficacy in multiple musculoskeletal conditions involving ligament and joint instability: Rabago et al

Clinical applications might include both acute ligament injuries and chronic ligamentous laxity or instability, though human efficacy data is needed to validate these potential indications

dose reduction of those agents may be required

However, peptides lack the large-scale randomized controlled trial evidence that supports biologics

However, a number of controlled trials with adjuvant chemotherapy in stage II and III patients did not demonstrate any therapeutic advantage