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The Journal of Clinical Endocrinology & Metabolism, 104 (11), 57035714
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Although the maximum plasma concentration is lower when compound 2 is administered PO (0.77 M) instead of IP (4.8 M), it is still 4.3-fold higher than LD 50 for ex vivo NTS determined in the commonly used 72 h assay, also indicating that TGR inhibitor 2 is orally bioavailable and the initial prediction of oral bioavailability based on the Lipinski et al
Coming off the Category 2 list is not FDA drug approval, and it is not the same as being cleared for compounding under section 503A
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