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and De Kok, L.J

By distributing the weekly dose into smaller, more frequent injections, the body may experience a smoother, more gradual introduction to the medication, potentially reducing the intensity of these side effects

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The divergence between elevated glucagon/GIP and lowered insulin and Cpeptide therefore highlights the context and sexdependent nature of incretin regulation, where GLP1RAs may exert variable effects on alphacell function depending on metabolic states and disease conditions (Nakashima et al