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A Review on Semaglutide: An Oral Glucagon-Like Peptide 1 Receptor Agonist in Management of Type 2 Diabetes Mellitus

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Brain slice immunofluorescence Mice were anesthetized with ketamine/xylazine 80/5 mg/kg (i.p.) and transcardially perfused with ice-cold PBS followed by 4% PFA in PBS

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( A L ) Plasma concentrations of GLP-1 (active) ( A ), insulin ( B ), leptin ( C ), PYY ( D ), C-peptide 2 ( E ), GIP (total) ( F ), amylin ( G ), glucagon ( H ), PP ( I ), ghrelin ( J ), resistin ( K ), and secretin ( L ) in 22- to 28-week-old female ad libitum chow-fed WT C57BL/6J and Bbs5 / mice ( n = 5 per group) before and after semaglutide therapy