[1] Furthermore, the dose escalation schedule for Wegovystarting at 0.25 mg weekly and gradually increasing to the maintenance dose of 2.4 mgis designed to improve tolerability, but each dose increase can temporarily intensify side effects, as noted in the SmPC
Key Insights Fatigue is a common but usually temporary side effect during the initial weeks or dose changes in GLP-1 therapy, caused largely by rapid calorie deficit, dehydration, and metabolic adjustments. Maintaining steady energy requires prioritising nutrient-dense meals rich in protein and complex carbohydrates, staying well hydrated, and managing electrolyte balance, which helps mitigate tiredness and supports overall metabolism. Gentle physical activity and good sleep hygiene are critical lifestyle adjustments that improve circulation, mood, and energy levels without overtaxing the body during the drug adaptation period. Persistent, worsening, or debilitating fatigue should prompt medical evaluation to exclude other causes, reassess medication dosing, and ensure safe continuation of GLP-1 therapy under healthcare supervision. Frequently asked questions Why do GLP-1 medications cause fatigue
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Whitney Linsenmeyer, PhD, RD, Assistant Professor of Nutrition and Dietetics Worsened Stomach Symptoms Gastric distress is among the most commonly reported side effects of semaglutide, especially in the beginning stages of taking the medication
This applies to five-panel, ten-panel, and twelve-panel urinalysis screens
