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Kuloglu, Caykoylu, Ekinci, & Yilmaz, 2009)

In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)

In the wake of the Oscar year, Lilly is stepping up distribution, including tablet versions of GLP-1, which are changing the treatment landscape

Reported readouts include integrin and TGF-linked regulation, changes in MMP-2 and extracellular-matrix turnover, and shifts in antioxidant and inflammatory-response elements in cell and animal models