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Park CH, Min SY, Yu HW, et al

Lean muscle may increase through resistance training, which improves metabolism but does not always show up as lower numbers on the scale

In light of the narrow therapeutic window defined by the balance between glucose-lowering efficacy and (so-called) gastrointestinal side effects, it seems unlikely that future long-acting GLP-1 receptor agonists will provide substantially greater efficacy without inducing more side effects compared with the already available compounds