these were bile acid metabolites such as cholate and chenodeoxycholate, lipid metabolites such as arachidonic acid, C16:0-LPC, C18:0-SM, docosapentaenoate, adrenic acid and stearoyl ethanolamide, metabolites involved in the metabolism of protein or amino acids, such as imidazole propionate, ADMA and creatine, and active metabolites or neurotransmitters such as the n-acetylputrescine, diacetylspermine, malonate
The human intestinal microbiome in health and disease
Lipotoxicity can trigger proteotoxic stress by altering ER integrity, fluidity, and/or structure, regardless of the levels of adequately folded ER proteins, 307,308,309 suggesting that there is crosstalk between proteotoxicity and lipotoxicity
Li H, Pei P, He Q, Dong X, Zhang C, Shen W, Chen H, Hu L, Tao Y, Yang K
The role of platelets in immune-mediated inflammatory diseases