However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)
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To investigate the impact of production methods on the stability and impurities of semaglutide drug substances and products and their potential impact on drug quality, efficacy, and safety RP-HPLC analysis was conducted using a C18 column with a mobile phase consisting of acetonitrile, isopropyl alcohol, water and 0.08 M ammonium phosphate [88]
Thermo Fisher Sci.) 29
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