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[3] Research published by the NIH: National Library of Medicine indicates that people with MTHFR mutations may require higher folate intake to maintain optimal homocysteine levels and overall methylation processes.[4] A study in JAMA Psychiatry suggested an association of individuals with MTHFR function and reports of mood

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Conclusion In summary, histamine functions as a neuromodulator in the brain and contributes to the central regulation of energy homeostasis