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10.3390/LIFE11080727 211 SmolarczykR.CichoT.PilnyE.Jarosz-BiejM.PoczkajA.KuachN.et al (2018)

These phases work sequentially to convert lipophilic toxins into water-soluble compounds that are less biologically reactive and suitable for elimination

That is why all patients treated on this study will get their own stem cells given back after the BSO/melphalan to decrease the side effects on the blood cells

However, the effect of oral vitamin B 12 varies among patients (13), and the available randomized controlled trials comparing the two treatment regimens are considered to be of low quality (14)

For the fed-batch culture in the 5-l bioreactor, medium containing 15 g/L Na 2 HPO 4 12H 2 O, 3 g/L KH 2 PO 4 , 0.5 g/L NaCl, 3 g/L NH 4 Cl, 0.2 g/L MgSO 4 7H 2 O, 0.011 g/L CaCl 2 , 0.5 mL/L vitamin B1 (1 % w/v), 0.5 mL/L of a stock solution of trace elements, and 4 g/L glucose was used