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2.1 The clinical signs The clinical signs of primary diffuse meningeal melanomatosis are very diverse: meningeal symptoms, mental disorders, and focal lesions of the cranial and spinal nerves, accompanied by peripheral paralysis and areflexia

FIGURE 1 UbiquitinProteasome System: A Complexed but Coordinated System The UPS is a highly controlled mechanism of protein degradation and turnover in cells, starting with monomeric ubiquitin, a small protein with a molecular mass of approximately 8 kDa (Johnson et al., 1995)

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Normal collagen synthesis, elastin, proteoglycan, and glucosaminoglycan production in the skin