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Smoking also may impair the phase II metabolites, thus creating more estrogen quinone metabolites with a decreased ability to eliminate them.[ref][ref] Therefore, the combo of variants in phase I and phase II genes (genotype report below) with smoking causes a fairly large increase in the risk of cervical, breast, or prostate cancer

Human APOE4 carriers may develop progressive BBB breakdown and pericyte degeneration, [101] early neurovascular dysfunction, [102] and reduced glucose uptake by the BBB

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