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Notably, there is no validated noninvasive marker to distinguish acute from chronic inflammation, and histological examination of biopsy samples is therefore required when clinically indicated

In rare cases, this can complicate the monitoring of malignant changes such as melanoma, potentially delaying diagnosis

BMC Genet 15(1):119 Li X, Wang S-J, Tan SC, Chew PL, Liu L, Wang L, Wen L, Ma L (2014) The A55T and K153R polymorphisms of MSTN gene are associated with the strength training-induced muscle hypertrophy among Han Chinese men

(PubMed) Giacosa A, Faliva MA, Perna S, Minoia C, Ronchi A, Rondanelli M