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Yes, semaglutide can cause fatigue, particularly during initial treatment due to gastrointestinal side effects, inadequate caloric intake, dehydration, or hypoglycemia when combined with insulin or sulfonylureas

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However, whether the weight loss can be sustained in the long term depends on several variables

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However, even slight variations, such as alterations in the dimensions of lipoprotein particles and an elevation in LDL II and IV subtypes, could potentially contribute to an increased susceptibility to macrovascular disease in people [107]