serotonin production emotional regulation stress tolerance cognitive flexibility repetitive patterns (as self-soothing) Traits commonly associated with undermethylation autism include: rigidity or insistence on sameness perfectionistic behavior high internal tension difficulty shifting attention anxiety or agitation during transitions Copper Overload Autism Emotional Intensity, Sensory Reactivity, and Poor Stress Tolerance Another major biochemical pattern identified in autism is copper overload , a condition in which there is too much unbound (free) copper circulating relative to ceruloplasmin, the protein that should bind and neutralize copper
Dysregulation in any of these regulatory nodes may induce ultrastructural mitochondrial abnormalities and functional impairments, ultimately precipitating axonal degeneration and neuronal apoptosispathological hallmarks that define neurodegenerative pathogenesis (Hong et al., 2024)
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In 2022, 389,485 new OSCC cases and 188,230 related deaths were reported worldwide, yielding a case-fatality rate of 48%, and its incidence continues to rise annually ( 2 Research progress on ferroptosis in OSCC 2.1 Mechanisms of ferroptosis Ferroptosis is a regulated form of cell death driven by the iron-dependent accumulation of lethal lipid peroxides