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Future research should focus on personalized antioxidant therapy guided by biomarker profiling to optimize clinical outcomes

Moreover, the preference for innovative and less invasive treatment options aligns well with the ongoing development of oral and long-acting formulations

Therapeutic implications and future directions Currently, the available evidence demonstrates that region-specific BBB dysfunction including reduced CBF (shortfalls and dysregulations), impaired BBB integrity (increased BBB permeability and transport system), and vascular inflammation (extravasated plasma components and peri-vascular inflammatory responses) contributes to the onset and progression of multiple neurodegenerative disorders

Given that GLP-1 RAs significantly reduce weight and improve metabolic health, millions of patients have become candidates for these drugs

Additionally, although the type of RYGB procedure was not randomly assigned, the balanced distribution of surgical techniques reduces the potential for confounding