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Network meta-analyses suggest that higher-dose semaglutide (1 mg and 2 mg weekly) and tirzepatide (a dual GIP/GLP-1 receptor agonist) demonstrate superior A1c reductions compared to other agents in the class, with mean reductions of 1.52.0% or greater from baseline

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The uORF is a region in the 5 untranslated region (UTR) of the mRNA transcript that often contains an additional start codon, as well as a stop codon [83]