Understanding tirzepatide's mechanism is essential when evaluating potential adverse effects, including concerns about pancreatic safety, as the incretin pathway has complex interactions with pancreatic tissue
Chen L, Yang XL
In mice fed Se deficient diets, testicular atrophy, reduced diameter of the seminiferous tubules, osseous metaplasia, and reduced spermatogenic activity were observed: no mitotic activity in spermatogonia, reduced the number of spermatogenic cell lines (including stem cells, pachytene spermatocytes, spermatids, and maturing sperms), and higher rates of abnormal morphology of sperm were found without difference in chromosomal abnormalities in spermatocytes (85, 100)
Uamek-Kozio M, Czuczwar SJ, Januszewski S, et al
Acetyl l-carnitine has been shown to combat this issue effectively