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Unlike fatigue from inadequate sleep, this type may persist despite rest

For the intestinal perfusions, a tube was placed in the proximal opening of the intestine, allowing luminal perfusion of 37C isotonic saline (0.9%) NaCl, at a rate of 0.035 mL/min

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Inter-individual variability in the absorption rate ( k a ), clearance (CL), intercompartmental clearance ( Q ), central volume ( V c ), and peripheral volume ( V p ) was explored using a log normal distribution in a model that included covariates with clear effects: drug product strength on the absorption rate constant and body weight as a covariate factor on CL, V c and V p