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12 , 16 Nose-to-Brain Delivery Efficiency of Nanoparticles Since intranasal administration can also lead to systemic drug circulation across the BBB and subsequent delivery of the drug into the brain, it is not feasible to directly measure the extent of nose-to-brain drug delivery

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In addition to these dimensions, the ARA 290 group differed as well in other dimensions, except for emotional role functioning and mental health