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Transplanting the gut microbiota from either obese or lean mice or humans into GF mice recapitulates the host phenotype, highlighting the potential causality of the gut microbiota in the development of metabolic dysregulation 252,253

Another key part of patient education is setting realistic expectations about weight loss

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Symptoms of vitamin B12 deficiency include (1): chronic fatigue shortness of breath heart palpitations tingling or numbness in the extremities poor balance loss of concentration poor memory disorientation mood changes incontinence insomnia People most at risk of developing a deficiency include older adults, as well as those who smoke, abuse alcohol, or follow a vegetarian or vegan diet

Nature Reviews Endocrinology