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Mild Systemic Effects Low-grade fatigue or energy fluctuation in the first day or two, particularly for first-time recipients Mild nausea is possible, especially if the injection is received on an empty stomach Slight headache , which often resolves with hydration Urine odor changes due to B12 and methionine metabolism harmless and expected Ingredient-Specific Notes: Methionine and Choline Not all side effects are generic to injections two ingredients in the MIC formula deserve a closer look because they have compound-specific effects in some people