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Conversely, Hantson and coworkers [83] recently reported the case of a 47-year-old epileptic man in whom parenteral VPA therapy was associated with a severe hyperammonaemic encephalopathy (peak ammonia concentration 411 mol/l) without any biological signs of hepatotoxicity

Participants took once-daily oral doses of aleniglipron, with doses increasing every four weeks, or received a placebo over 36 weeks

Most changes resolve within 36 months as metabolism stabilizes

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In addition, undergoing combined procedures is often a good way to minimize needed downtime: the recovery periods are not additive