In db/db mouse models of advanced diabetes characterized by uncontrolled hyperglycemia and catabolic weight loss, PG-102 achieved superior and sustained glycemic control compared with semaglutide or tirzepatide while preserving body weight, uncoupling glycemic control from catabolic weight loss
While several studies examined GPx activity [63, 71, 72, 74, 81, 83, 84] or its polymorphisms [94, 95], only one examined glutathione reductase or glutathione-S-transferase activity [85]
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