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Although affinity-based screening technologies such as phage and yeast display enable the high-throughput screening of large combinatorial peptide libraries, they rely on the use of recombinant protein or membrane preparations and do not distinguish between agonists, inverse agonists and antagonists

This sampling approach misses temporal dynamics, circadian variation, and subtle early signals

Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations