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Biofilm-resident bacteria exhibit a reduced metabolism and an altered proteome compared to their planktonic counterparts, features that contribute to their reduced susceptibility to immune effectors and commonly used antibiotic treatments (Novotny et al., 2019)

Dihexa was administered to aduts male Sprague Dawley rats at lOmg/kg

doi: 10.1007/978-3-030-11488-6_3 158 GordonDMBlomquistTMMiruzziSAMcCullumsmithRStecDEHindsTD

above approximately pH 7.4 the Cu(II) chelate begins to release copper and the solution darkens