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Semaglutide supports weight loss by reducing appetite

Although several recent preclinical studies using obese or diabetic models have demonstrated broadly consistent cardioprotective effects in line with CVOTs with GLP-1RAs, wider implementation of obesity/diabetes experimental models will be crucial to strengthen the translational link between preclinical mechanisms and clinical outcomes

Maximum efficacy at 15mg delivered 20.9% weight reduction

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Researchers who assume short half life equals short effect duration are applying the wrong mental model