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Semaglutide might indirectly improve CV and kidney-related outcomes, but the exact mechanisms by which GLP-1RAs exert beneficial effects on CV and kidney parameters are not yet elucidated, in contrast to the well-established intrarenal tubulo-glomerular feedback mechanism of SGLT2is [13]

doi:10.18553/jmcp.2014.20.12.1183 Rosenstock J, Wysham C, Fras JP, et al

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Setmelanotide was also associated with increases in heart rate followed by a compensatory drop in blood pressure after 0.5 mg/kg bolus SC injections in NHPs (97)