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Differential methylation patterns were observed in our methylome dataset for the LuxR family genes dctP (Dde_2216, PM_CB = 0.61, PM_CuB = 0.80) and dctQ (Dde_1274, PM_CB = 0.52, PM_CuB = 0.56) (Supplementary File S11)

For prescription topical formulations used consistently, initial improvements in texture, hydration, and radiance typically appear at 2 to 4 weeks, meaningful visible changes to firmness and fine lines at 4 to 8 weeks, maximum early results at 8 to 12 weeks, and full cumulative benefit at 3 to 6 months of consistent daily use

For example GSH has been shown to be important for the regulation of cellular labile copper pools 116

Tretinoin has been used for decades with a well-established safety profile