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The TRAP telomerase assay confirms that TERT activation is the upstream driver: TERT knockdown (siRNA) abolishes Epitalons anti-senescence effect, while TERT overexpression (viral vector) phenocopies it without Epitalon establishing TERT as the essential effector

Any patient on this combination should be checking blood pressure and resting heart rate at minimum weekly, with clear thresholds established for when to reduce or discontinue one or both medications