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This is partly due to the caloric deficit the medication creates

It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number

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Priyadarshini, D., Ivica, J., Separovic, F., and de Planque, M., Biophys