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Chens research found that GLP1R and SGLT2 expression was significantly downregulated in DR patients and negatively correlated with high expression levels of pro-inflammatory cytokines such as tumour necrosis factor (TNF-) and interferon (IFN-)

Some small studies show modest lightening effects, but large randomized trials in diverse populations are lacking

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This GLP-1-mediated delivery of oestrogen to specific tissues enhanced body weight loss and improved glycaemic control and insulin sensitivity relative to either of the hormones alone in DIO mice [96]

It could be a sign of low B12 levels