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The microglial cells secrete a series of pro-inflammatory cytokines, such as interleukin-1 ( IL-1 ), tumor necrosis factor-alpha ( TNF-), and interleukin-6 ( IL-6 ), which heighten neuronal sensitivity and impair standard nociceptive processing [22]

Soluble intracellular adhesion molecule 1 (sICAM-1) was significantly decreased with treatment (Figure 7I)

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