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For instance, upon binding to GPR43, propionate activates AMPK through Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK), thereby inhibiting the expression of key gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), which reduces hepatic glucose output (64)

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Your digestion has slowed down, your cravings have shifted, and you need every bite to deliver maximum nutrition