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A supplement regimen of 400 g of folic acid, 2 mg of vitamin B 6 , and 6 g of vitamin B 12 has been advocated by the American Heart Association if an initial trial of a folate-rich diet (see Sources) is not successful in adequately lowering homocysteine concentrations (95)

It also determined an upper limit for benefit, as doses at 25 uM led to a reduction in gene expression and more sunburn damage

Although the majority of adult males and females in the United States consume more than the daily recommended intake of sulfur amino acids (90), these GSH losses can be of importance during prolonged states of protein/energy insufficiency (including catabolic illness) or in individuals with chronic inflammatory illnesses such as alcoholism where GSH stores are otherwise depleted (94, 352)

10.1038/sj.bjp.0706290 Br

Biomater Sci 12:53865403