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Available online at: (Accessed February 13, 2025)

Chronic inflammation plays a central role in weight gain, metabolic dysfunction, and cardiovascular disease

CB1 inhibition is a differentiated energy-modulating and fat-burning mechanism with evidence showing its capability to induce weight loss

Although these findings raise concerns, the direct applicability to human risk remains uncertain, underscoring the importance of conducting additional studies to assess the carcinogenic effect, especially the thyroid carcinogenic risk associated with semaglutide, given the in vitro study findings [18,19]

Our team at Cape Fear Physical Medicine and Rehab is committed to providing personalized care and thorough guidance throughout your treatment