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Keatings lab spent many years designing peptides that would bind to the section of Mcl-1 involved in this interaction but not to other members of the protein family

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PMID: 35658024): The study showed mean weight reduction of 15.0% , 19.5% , 20.9% vs 3.1% placebo at 72 weeks The study showed up to 36% of participants achieved 25% or more weight loss with tirzepatide 15 mg Tirzepatide Once Weekly for the Treatment of Obesity in People with Type 2 Diabetes (SURMOUNT-2) , published in The Lancet (Garvey WT et al., 2023

Oral and topical glutathione are generally well tolerated in studies and appear to be safe at typical doses, although long-term data are limited