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doi:10.1016/S0140-6736(23)01053-X PubMed: This trial evaluated retatrutide in 281 participants with type 2 diabetes, showing up to 16.94% weight loss and significant HbA1c reductions with favorable safety profile comparable to other GLP-1 based therapies

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Screening for other causes of persistent fatigue is important

The role of GLP-1 receptor agonists in opioid addiction is still under investigation, but initial studies suggest that these drugs could reduce the rewarding effects of opioids, making them less appealing to users

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