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As CIBB is designed on the basis of the CXC10 regions that bind to IL18R1 with high affinity, CIBB blocks only the binding of CXCL10 to IL18R1 without affecting the positive role of CXCL10 in suppressing tumor growth

Staying superficial in the subcutaneous layer and avoiding the femoral triangle helps ensure safe administration

Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme in the detoxification of 4-HNE [86]

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