Semaglutide, a GLP-1 receptor agonist, has offered a potential solution to this pressing problem
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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
The short answer is that it can, but it usually shouldn'tespecially if you choose the right format