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The company has already demonstrated the value of its technology in two approved products, namely Yorvipath (palopegteriparatide), a modified version of parathyroid hormone (PTH), which is for the treatment of hypoparathyroidism in adults, and Skytrofa (lonapegsomatropin), a long-acting growth hormone for children with growth hormone deficiency

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[PubMed: 25631887] For many workflows, labs keep a master vial protected from routine handling, and prepare smaller working aliquots to reduce exposure

It is interesting to note that a selective ablation of the BDNF gene from the ventral tegmental area induced antidepressant-like effect in the social defeat stress paradigm, 57 whereas in this study, BDNF reduction in the vSUB resulted in anhedonic-like behavior

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