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= Hormon- und Stoffwechselforschung = Hormones metabolisme (2008) 40(9):593606

Proposed mechanisms for hepatocyte necrosis include extreme hypertrophy leading to reduced sinusoidal blood circulation, hypoxia, and necrosis (Slauson and Cooper 2001) and/or metabolic activation forming more toxic active metabolites (Farber 1980)

The recommendations, published in the medical journal JAMA, emphasize that these medications alone are not a solution to treating the global obesity epidemic

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