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Therefore, the same mechanism that contributes to the therapeutic benefits of ACE inhibitors can also lead to one of their most common adverse effects

Diabetes Res Clin Pract 2015;110:2637

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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

Fedeli U, Barbiellini Amidei C, Casotto V, et al