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10.1038/s41467-018-06893-9 311 XiongL.TengJ

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High Whole-Blood Histamine and Undermethylation In the Walsh Approach, elevated whole-blood histamine may occur with seasonal allergies, depression, OCD traits, perfectionism, inner tension, high achievement and poor tolerance of folate supplements

Two pathways, the glutaredoxin and thioredoxin pathways, function in parallel, with the thioredoxins reduced by thioredoxin reductase (trxB) and the glutaredoxins reduced by glutathione, which is maintained in its reduced state by glutathione reductase (gor)