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It is activated by voltage-dependent Ca 2+ -channels, as well as neurotransmitter and hormone receptors, that increase intracellular Ca 2+ and cause accumulation of the Ca 2+ -calmodulin complex

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Cafestol increases the translocation of NRF2 and increases the expression of heme oxygenase (HO)-1, possibly by interacting with Keap1 [69]

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